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Blood Clots after COVID-19 Vaccination

Published Reports Represent the Tip of the Iceberg

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By Peter A. McCullough, MD, MPH

Recently Health Feedback, a pro-vaccine false counterclaim, fact-checker blogging website made this statement:

When discussing safety, case reports always represent the tip of the iceberg since not all patients are contacted regarding health events after serial exposures to EUA mRNA or adenoviral DNA vaccination. I did a literature search on PUBMED and found 1046 listings for “COVID-19 vaccine” and “thrombosis.”

Woo, et al, from the Office of Biostatistics and Pharmacovigilance, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring Maryland, reported a large number of blood clots in the US from the Janssen adenoviral DNA COVID-19 vaccine. They describe clots extending from the ankle to the groin. I have seen this in my practice with both mRNA and adenoviral vaccines. This nothing like I have seen before.

Woo EJ, Mba-Jonas A, Thomas A, Baer B, Day B, Kim Y, Gomez-Lorenzo M, Nair N. Thromboembolic events after Ad.26.COV2.S COVID-19 vaccine: Reports to the Vaccine Adverse Event Reporting System. Pharmacoepidemiol Drug Saf. 2022 Nov;31(11):1174-1181. doi: 10.1002/pds.5523. Epub 2022 Sep 5. PMID: 36065046; PMCID: PMC9538147.

Bekal et al, reported cases of obvious mRNA vaccine induced thrombosis. When measured, the D-dimer was a tip off that Spike-protein had triggered the coagulation cascade. Note the clots are in temporal relationship to the vaccine administration, not COVID-19 illness.

Bekal S, Husari G, Okura M, Huang CA, Bukari MS. Thrombosis Development After mRNA COVID-19 Vaccine Administration: A Case Series. Cureus. 2023 Jul 4;15(7):e41371. doi: 10.7759/cureus.41371. PMID: 37546104; PMCID: PMC10400017.

Kaimori et al reported autopsy findings in a 72 year-old woman with diffuse large B-cell lymphoma of the stomach, a who died at home 2 days after taking Pfizer. The body was riddled with micro-blood clots (thrombotic microangiopathy [TMA]).

Kaimori R, Nishida H, Uchida T, Tamura M, Kuroki K, Murata K, Hatakeyama K, Ikeda Y, Amemiya K, Nishizono A, Daa T, Mori S. Histopathologically TMA-like distribution of multiple organ thromboses following the initial dose of the BNT162b2 mRNA vaccine (Comirnaty, Pfizer/BioNTech): an autopsy case report. Thromb J. 2022 Oct 6;20(1):61. doi: 10.1186/s12959-022-00418-7. PMID: 36203145; PMCID: PMC9540301.

In a 2023 systematic review of the literature, Tan et al, reported:

“A total of over 24,000 thrombotic events have been reported, the majority of which have been associated with adenoviral vector-based vaccine, particularly AstraZeneca (5 in 100,000 up to 6 in 1000), followed by Janssen (8–30 in 1,000,000 doses), Pfizer (6 in 1,000,000 up to 1 in 1000 doses) and Moderna (4 in 10,000,000). Antibodies against platelet factor 4 (PF 4) were positive in 67 cases in AstraZeneca and 17 cases in Janssen, and it was not tested or mentioned in cases of mRNA-based vaccine. Overall, the thrombotic event is more frequently occurred after 1st dose of AstraZeneca vaccine (Table 3). Death related with thrombotic event was registered 238 cases in Pfizer, 186 cases in AstraZeneca, 54 cases in Moderna and 17 cases in Janssen.”

This brief exercise demonstrates how dangerous false counterclaims can be made by uncredentialed, internet blogger services deceiving the public on vaccine safety. My advice is to follow highly credentialed doctors taking care of patients in their practice with side effects after the vaccine. Any blogger downplaying safety concerns is a public health risk. Always, safety first.

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Peter A. McCullough, MD, MPH

President, McCullough Foundation

http://www.mcculloughfnd.org

Woo EJ, Mba-Jonas A, Thomas A, Baer B, Day B, Kim Y, Gomez-Lorenzo M, Nair N. Thromboembolic events after Ad.26.COV2.S COVID-19 vaccine: Reports to the Vaccine Adverse Event Reporting System. Pharmacoepidemiol Drug Saf. 2022 Nov;31(11):1174-1181. doi: 10.1002/pds.5523. Epub 2022 Sep 5. PMID: 36065046; PMCID: PMC9538147.

Bekal S, Husari G, Okura M, Huang CA, Bukari MS. Thrombosis Development After mRNA COVID-19 Vaccine Administration: A Case Series. Cureus. 2023 Jul 4;15(7):e41371. doi: 10.7759/cureus.41371. PMID: 37546104; PMCID: PMC10400017.

Kaimori R, Nishida H, Uchida T, Tamura M, Kuroki K, Murata K, Hatakeyama K, Ikeda Y, Amemiya K, Nishizono A, Daa T, Mori S. Histopathologically TMA-like distribution of multiple organ thromboses following the initial dose of the BNT162b2 mRNA vaccine (Comirnaty, Pfizer/BioNTech): an autopsy case report. Thromb J. 2022 Oct 6;20(1):61. doi: 10.1186/s12959-022-00418-7. PMID: 36203145; PMCID: PMC9540301.

Tan LJ, Koh CP, Lai SK, Poh WC, Othman MS, Hussin H. A systemic review and recommendation for an autopsy approach to death followed the COVID 19 vaccination. Forensic Sci Int. 2022 Nov;340:111469. doi: 10.1016/j.forsciint.2022.111469. Epub 2022 Sep 20. PMID: 36162300; PMCID: PMC9487151.

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